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Depending on the present Outbreak of childhood hepatitis that may be associated with adenovirusAccording to the recent Centers for Disease Control and Prevention (CDC), current data show childhood hepatitis cases or adenovirus type 40 from the onset of the outbreak compared to pre-COVID-19 pandemic levels. We found that it did not suggest an increase in / 41 and a weekly mortality report.
“We analyzed data from four large government databases to assess predisposition to childhood hepatitis and the proportion of adenovirus 40/41 positive fecal specimens,” the CDC said.
“This ecological analysis cannot definitively confirm or refute the potential link between childhood hepatitis and adenovirus, but it does provide a useful context for ongoing investigation.”
The CDC has collected data from the current hepatitis outbreak period from October 2021 to March 2022, as COVID-19 may have changed the behavior of seeking medical care in 2020-21 in response to a pandemic. Compared to the previous pandemic baseline.
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After pediatric cases of hepatitis began to be identified in the United States and the United Kingdom without a clear etiology, the CDC issued a healthy recommendation in April 2022 to report additional cases.
They also have adenovirus type 41, a virus that is known to cause gastroenteritis in many of the reported cases, but is not known to cause hepatitis in children whose immune system is not compromised. We found that the test result was positive.
“Neither acute hepatitis of unknown etiology nor adenovirus type 41 has been reported in the United States, so it is unclear whether either has recently increased beyond historical levels,” the CDC said.
Therefore, the agency analyzed data from four sources: National Syndromic Surveillance Program (NSSP), Premier Healthcare Database Special Release (PHD-SR), Organ Procurement and Transplant Network (OPTN), and Labcorp.
NSSP collects electronic health information from the emergency departments of all states in the United States and the District of Columbia. That’s 71% of the non-federal emergency rooms in the United States.
The PHD-SR contains records from approximately 1,000 hospitals, and pediatric liver transplant data was obtained from a national registry maintained by OPTN.
Labcorp data included the results of fecal specimens tested for adenovirus type 40/41, but it was not possible to distinguish between types 40 and 41, but CDC reported gastroenteritis in the United States. Approximately 90% of all adenovirus cases detected in were type 41.
There was no significant difference in hospitalization associated with hepatitis or pediatric emergency visits during the outbreak from October 2021 to March 2022 compared to before the COVID-19 pandemic.
Also, there was no significant increase in the number of monthly liver transplants or the proportion of adenovirus type 40/41 positive specimens between October 2021 and March 2022 compared to pre-pandemic levels. ..
However, the UK reported an increase in the number of adenovirus-positive stool specimens among children aged 1 to 4 years compared to pre-pandemic levels, but with respect to the total number of specimens tested in the UK. Adenovirus-positive specimens are unknown because no data are available.
The CDC reports that data are limited as cases of hepatitis without a clear cause cannot be reported in the United States and the analysis indirectly assessed hepatitis propensity through electronic health data. Therefore, the exact baseline is currently unknown.
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They also said that liver transplants are “well documented”, but the March 2022 data may be underreported due to the 2-3 month delay in reporting. I am.
In addition, the pre-pandemic data is limited to 2017-2019, as the COVID-19 pandemic may have changed health-seeking behavior, and it is unclear if this data is an accurate baseline.
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The CDC also noted that hepatitis cases are rare, so small sample sizes can make it difficult to determine small changes in incidence.
“Finally, these results aim to provide an overview of trends in unexplained childhood acute hepatitis and adenovirus type 40/41 in the United States, inferring or disproving a causal relationship between these two diseases. Cannot be used for. ”